If you’re struggling with weight loss resistance, low energy, insulin resistance, or metabolic dysfunction, MOTS-C may be the breakthrough therapy you’ve been looking for.

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring peptide encoded within mitochondrial DNA, the powerhouses of your cells. Discovered in 2015, MOTS-C has emerged as one of the most promising peptides for metabolic optimisation, longevity, and disease prevention.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded by the mtDNA MT-RNR1 gene, which acts as a "mitochondrial hormone" to regulate metabolism, insulin sensitivity, and exercise adaptation.

It acts primarily on skeletal muscle to enhance fatty acid oxidation and glucose metabolism.

Key Functions and Effects of MOTS-C

Metabolic Homeostasis: Promotes energy balance by inhibiting the folate-purine-AMPK pathway, which helps manage insulin resistance and obesity.
Exercise Mimicry: Levels of MOTS-c increase significantly during exercise (~12-fold), improving physical performance and muscular adaptation.
Anti-Aging and Stress Protection:
Acts as a signalling molecule that moves to the nucleus under metabolic stress to regulate protective genes
Therapeutic Potential: Research suggests it may help with age-related diseases, including diabetes, osteoporosis, and cardiovascular issues.

Biological Mechanism

Unlike most peptides, MOTS-c is encoded in the mitochondria rather than the nucleus. It is released into circulation and targets skeletal muscle, acting as a signalling molecule that declines with age, contributing to age-related metabolic decline.