KPV (Lysine-Proline-Valine) is a potent, naturally occurring anti-inflammatory tripeptide derived from MSH, commonly used in 10mg doses for research or therapeutic applications to manage inflammation, gut health (colitis, IBS), and skin issues. It acts as a powerful anti-inflammatory and antimicrobial agent.

Key Aspects of KPV 10mg:

Primary Uses: It is used to combat inflammatory bowel disease (IBD), Crohn's disease, and leaky gut. It is also very effective for skin conditions like acne and eczema.
Mechanisms: KPV works by directly inhibiting inflammatory signalling pathways, including TNF-
mRNA expression, and it helps accelerate tissue healing.

A Potent Anti-Inflammatory Tripeptide KPV, or Lysine-Proline-Valine, is a naturally derived tripeptide that originates from the alpha-Melanocyte Stimulating Hormone (alpha-MSH). While it shares the potent anti-inflammatory properties of its parent hormone, it does so without triggering any pigmenting effects. This makes KPV a highly specialised tool for managing systemic inflammation, particularly within the digestive tract and on the skin, where it works to neutralise inflammatory pathways at a cellular level.

Targeting Gut Health and Digestive Balance One of the most significant applications of KPV is its ability to support the lining of the gut. Research indicates that it interacts directly with intestinal epithelia cells to reduce the production of pro-inflammatory cytokines. By inhibiting the NF-kappaB signalling pathway, KPV helps to settle the gut and may assist in the management of chronic inflammatory bowel conditions. This targeted action helps in maintaining a healthy microbiome and improving the overall integrity of the digestive system.

Antimicrobial and Healing Properties Beyond its anti-inflammatory capabilities, KPV has demonstrated notable antimicrobial activity. It is frequently utilised in research to combat various pathogens, including certain bacteria and fungi. When applied to the skin or used systemically, it assists the body’s natural defence mechanisms, accelerating the healing process for wounds, burns, and irritated skin. This dual action of reducing swelling whilst fighting microbes makes it a versatile compound for restorative health.

Mechanism of Cellular Signalling At the molecular level, KPV operates by entering cells and interacting with specific receptors that govern the immune response. Because it is a very small molecule, it can easily cross cell membranes to exert its influence directly on the nucleus. This allows for a rapid reduction in redness and swelling, as the peptide effectively signals the body to "switch off" the inflammatory response, providing a more balanced internal environment.

Stability and Storage for Maximum Efficacy To ensure the purity and potency of this 10 mg KPV vial, the peptide is stabilised through a high-precision lyophilisation (freeze-drying) process. This method preserves the structural integrity of the amino acids, ensuring the product remains effective during transit. For long-term storage, it is recommended to keep the vial in a refrigerated environment between 2°C and 8°C. Once reconstituted, the solution should be handled with care and utilised within the recommended timeframe to maintain its biological activity.